To date, the effective management of HIV‐1 infection by anti‐retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV‐1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral‐type zinc finger structures found in the HIV‐1 nucleocapsid protein as targets for anti‐retroviral drugs(1). The second demonstrated the feasibility of (...) the reverse transcriptase inhibitor (R)‐9‐(2‐phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV‐1 infection(2). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Proust and the Phenomenology of MemoryThomas M. Lennon"I still believe that anything that I do outside of literature and philosophy will be so much time wasted." Thus did the twenty-two year old Marcel Proust (1871–1922) write to his father, reluctantly agreeing to consider a career in the foreign service as an alternative to the legal profession otherwise being urged upon him. ("I should vastly prefer going to work for (...) a stockbroker," was his comment.)1 Happily for us all, Proust was obliged to do neither, and in fact was able to do both philosophy and literature. As André Maurois puts it, "[Proust's] great novel is philosophy incarnate."2 Certainly, In Search of Lost Time is saturated with philosophy, the appreciation of which cannot help but enhance our understanding of this great work. The thesis here will be that a loosely phenomenological account of the work's central concept of memory gives us the structure of the work as a whole.The biographical facts suggest such an approach. Proust received a license from the Sorbonne in 1895, and, more importantly, had previously been a student of the philosopher Alphonse Darlu at the Lycée Condorcet. Although he published very little, Darlu was a charismatic, inspirational figure for his students—not least of all for Proust himself, who described him as "the great philosopher whose inspired words, more certain to last than any writing would, gave birth in me as in so many others to thought itself."3 A touching artifact of Proust's time with Darlu is his report card, preserved in the Proust Museum at Illiers-Combray. Not incidentally, it shows a concentration on the classical authors who will be deployed here. We also have a wonderful little text that argues a kind of phenomenalism influenced perhaps by Hume, and certainly by Kant.4 The one author important to our account whose name does not figure as such in any of this material is Malebranche; but we know [End Page 52] that Proust was familiar with the great Oratorian since he quotes him.5 In fact, the only author appearing below who could not have been on Proust's shelf is Kundera, the most philosophical and Proustian of all recent novelists.We begin with a text; it is the most famous of all in French literature, the episode of the madeleine from the Search. The text has become so well known—through hearsay more than from having been read, no doubt—that it has invited "kitchification."6 Even so, it is an exquisite piece of writing, which, in any case, is essential to the thesis here.Many years had elapsed during which nothing of Combray... had any existence for me, when one day in winter as I came home, my mother, seeing that I was cold, offered me some tea, a thing that I did not ordinarily take.... She sent out for one of those plump little cakes called 'petites madeleines'.... I raised to my lips a spoonful of the tea in which I had soaked a morsel of the cake. No sooner had the warm liquid, and the crumbs with it, touched my palate than a shudder ran through my whole body.... And suddenly the memory [le souvenir] returns. The taste was that of the little crumb of 'madeleine' which on Sunday mornings at Combray... my Aunt Léonie used to give me, dipping it first in her own cup of real or lime-flower tea.... Immediately the old grey house upon the street rose up like the scenery of a theatre... in a moment all the flowers in our garden and in M. Swann's park, and the water-lilies on the Vivonne and the good folk of the village and their little dwellings and the parish church and the whole of Combray and of its surroundings, taking their proper shapes and growing solid, sprang into being, town and gardens alike, from my cup of tea.7There are other such episodes of the past springing into being, but not many, and they occur but infrequently, until the very end of this vast work, when they come upon the narrator rapidly and almost... (shrink)

This paper discusses contemporary advancements in the affective sciences that can inform the music-emotion literature. Key concepts in these theories are outlined, highlighting their points of agreement and disagreement. This summary shows the importance of appraisal within the emotion process, provides a greater emphasis upon goal-directed accounts of behavior, and a need to move away from discrete emotion “folk” concepts and toward the study of an emotional episode and its components. Consequently, three contemporary music emotion theories are examined through a (...) skeptical lens. This critique highlights the over-reliance upon categorization and a lack of acknowledgment of appraisal processes, specifically goal-directed appraisal, in examining how individual experiences of music emerge in different contexts. Based on this critique of current music-emotion models, we present our skeptically informed CODA model - Constructivistly-Organised Dimensional-Appraisal model. This model addresses skeptical limitations of existing theories, reinstates the role of goal-directed appraisal as central to what makes music relevant and meaningful to an individual in different contexts and brings together different theoretical frameworks into a single model. From the development of the CODA model, several hypotheses are proposed and applied to musical contexts. These hypotheses address theoretical issues such as acknowledging individual and contextual differences in emotional intensity and valence, as well as differentiating between induced and perceived emotions, and utilitarian and aesthetic emotions. We conclude with a sections of recommendations for future research. Altogether, this theoretical critique and proposed model points toward a positive future direction for music-emotion science. One where researchers can take forward testable predictions about what makes music relevant and meaningful to an individual. (shrink)

Philosophical arguments often assume that the folk tends towards moral objectivism. Although recent psychological studies have indicated that lay persons’ attitudes to morality are best characterized in terms of non-objectivism-leaning pluralism, it has been maintained that the folk may be committed to moral objectivism _implicitly_. Since the studies conducted so far almost exclusively assessed subjects’ metaethical attitudes via explicit cognitions, the strength of this rebuttal remains unclear. The current study attempts to test the folk’s implicit metaethical commitments. We present results (...) of a newly developed Implicit Association Test (IAT) for metaethical attitudes which indicate that the folk generally tend towards moral non-objectivism on the implicit level as well. We discuss implications of this finding for the philosophical debate. (shrink)

The study of intellectual humility is still in its early stages and issues of definition and measurement are only now being explored. To inform and guide the process of defining and measuring this important intellectual virtue, we conducted a series of studies into the implicit theory – or ‘folk’ understanding – of an intellectually humble person, a wise person, and an intellectually arrogant person. In Study 1, 350 adults used a free-listing procedure to generate a list of descriptors, one for (...) each person-concept. In Study 2, 335 adults rated the previously generated descriptors by how characteristic each was of the target person-concept. In Study 3, 344 adults sorted the descriptors by similarity for each person-concept. By comparing and contrasting the three person-concepts, a complex portrait of an intellectually humble person emerges with particular epistemic, self-oriented, and other-oriented dimensions. (shrink)

In Preference, Value, Choice, and Welfare, I argued, among other things, that preferences in economics are and ought to be total subjective comparative evaluations, that the theory of rational choice is a reformulation of everyday folk-psychological explanations and predictions of behaviour, and that revealed preference theory is completely untenable. All three of these theses have been challenged in essays by Erik Angner (2018), Francesco Guala (2019) and Johanna Thoma (2021a, 2021b). This essay responds to these criticisms and defends these three (...) theses. (shrink)

Thomas Aquinas produced a voluminous body of work on moral theory, and much of that work is on virtue, particularly the status and value of the virtues as principles of virtuous acts, and the way in which a moral life can be organized around them schematically. Thomas Osborne presents Aquinas's account of virtue in its historical, philosophical and theological contexts, to show the reader what Aquinas himself wished to teach about virtue. His discussion makes the complexities of Aquinas's (...) moral thought accessible to readers despite the differences between Thomas's texts themselves, and the distance between our background assumptions and his. The book will be valuable for scholars and students in ethics, medieval philosophy, and theology. (shrink)

ABSTRACT:Many scholars and managers endorse the idea that the primary purpose of the firm is to make money for its owners. This shareholder wealth maximization objective is justified on the grounds that it maximizes social welfare. In this article, the first of a two-part set, we argue that, although this shareholder primacy model may have been appropriate in an earlier era, it no longer is, given our current state of economic and social affairs. To make our case, we employ a (...) utilitarian moral standard and examine the apparent logical sequence behind the link between shareholder wealth maximization and social welfare. Upon close empirical and conceptual scrutiny, we find that utilitarian criteria do not support the shareholder model; that is, shareholder wealth maximization is only weakly linked to social welfare maximization. In view of the dubious validity of this sequential argument, we outline some of the features of a superior corporate objective—a variant of normative stakeholder theory. In the second article, we will advance and defend our preferred alternative and then discuss some institutional arrangements under which it could be implemented. (shrink)

ABSTRACT:Employing utilitarian criteria, Jones and Felps, in “Shareholder Wealth Maximization and Social Welfare: A Utilitarian Critique” (Business Ethics Quarterly23[2]: 207–38), examined the sequential logic leading from shareholder wealth maximization to maximal social welfare and uncovered several serious empirical and conceptual shortcomings. After rendering shareholder wealth maximization seriously compromised as an objective for corporate operations, they provided a set of criteria regarding what a replacement corporate objective would look like, but do not offer a specific alternative. In this article, we draw (...) on neo-utilitarian thought to advance a refined version of normative stakeholder theory that we believe addresses a major remaining criticism of extant versions, their lack of specificity. More particularly, we provide a single-valued objective function for the corporation—stakeholder happiness enhancement—that would allow managers to make principled choices between/among policy options when stakeholder interests conflict. (shrink)

This paper is reprinted in the book Machine Ethics, eds. M. Anderson and S. Anderson, Cambridge University Press, 2011.

Time-limited trials of intensive care have arisen in response to the increasing demand for intensive care treatment for patients with a low chance of surviving their critical illness, and the clinical uncertainty inherent in intensive care decision-making. Intensive care treatment is reported by most patients to be a significantly unpleasant experience. Therefore, patients who do not survive intensive care treatment are exposed to a negative dying experience. Time-limited trials of intensive care treatment in patients with a low chance of surviving (...) have both a small chance of benefiting this patient group and a high chance of harming them by depriving them of a good death. A ‘rule of rescue’ for the critically unwell does not justify time-limiting a trial of intensive care treatment and overlooks the experiential costs that intensive care patients face. Offering time-limited trials of intensive care to all patients, regardless of their chance of survival, overlooks the responsibility of resource-limited intensive care clinicians for suffering caused by their actions. A patient-specific risk–benefit analysis is vital when deciding whether to offer intensive care treatment, to ensure that time-limited trials of intensive care are not undertaken for patients who have a much higher chance of being harmed, rather than benefited by the treatment. The virtue ethics concept of human flourishing has the potential to offer additional ethical guidance to resource-limited clinicians facing these complex decisions, involving the balancing of a quantifiable survival benefit against the qualitative suffering that intensive care treatment may cause. (shrink)

Thomas Alexander shows that the primary, guiding concern of Dewey's philosophy is his theory of aesthetic experience.

This volume comprises essays presented to Alvin Plantinga on the occasion of his 70th birthday.

A consideration of the full dimensions of humanism and of the humanist dimension of law invites two questions: is “humanism” compatible with theocentric religion, and therefore, is the Renaissance compatible with the “otherworldly” Middle Ages, and, has law any humanist dimension at all? The answer to the first question provides the insights that answer the second. Fully integrated humanism includes bath the Classical immanence of humanity in the world and the value accorded to the human being by the declaration in (...) Genesis that all creation is “very good”, a principle reinforced by the Incarnation of the Logos as a man. Understood in the full range of its human relevance, from the quotidian to the transcendent, law too bas a humanist dimension. (shrink)

The paper aims to put certain basic mathematical elements and operations into an empirical perspective, evaluate the empirical status of various analytic operations widely used within psychology and suggest alternatives to procedures criticized as inadequate. Experimentation shows the "manyness" of items to be a perceptual quality for both young children and animals and that natural operations are performed by naive children analogous to those performed by persons tutored in arithmetic. Number, counting, arithmetic operations therefore can make distinctions that are not (...) inevitably arbitrary, and conceptual operations can obviously have a status as natural events with psychology. If the elements and conceptual operations involved in mathematical systems were not inherent in physiological process, various primitive discriminations could not be possible. Also, since some calculi have a natural status in a given empirical circumstance, the axioms of others can not be satisfied. Therefore the psychologist when acting as an empirical scientist seeks a calculus having a structure whose elements are isomorphic with natural units of stimulus and response and whose operations are isomorphic with whatever natural processes are involved. Measurement poses a special problem for the empirical scientist. It concerns but a single class of natural qualities and this only in a limited way. The concept of quantity has a natural counterpart but quantity and measurement are not wholly analogous. Measurement is defined, as H. S. Leonard suggests, as a theoretical activity. Measurement theory has a formal structure but empirical end. Measurement hypothesizes about the position of a particular quality within a definite range of qualities. It therefore is beholden to definite empirical restrictions. Some hypotheses-making systems use terms and relations per se as the context and starting point for dealing with discriminable events. Such procedures are 'transcendent." In empirical science, questions are part of problem-solving activity and their reference is naturally restricted. In providing description and explanation, psychological researchers frequently use calculi in a transcendent way. This results in theories that are only quasi-empirical and "half" true. The roles measurement plays in psychology are discussed. Of particular concern are those cases in which the results of measuring or a theory of measurement are used to define the "real" units, or the "real" relations involved in problematic psychological events, and thence to describe and explain behaviors of interest. Metaphysical or ontological usages of measurement sometimes occur. The implication of these arguments with regard to a view of empirical science is discussed. (shrink)

The essay on thirteenth-century ethics will trace the history of three major themes in moral philosophy and theology, namely the morality of individual acts, virtue, and happiness. Both Peter Lombard’s rejection of Abelard’s focus on intention and the Fourth Lateran Council’s remarks on confession caused thinkers such as William of Auvergne and Philip the Chancellor to develop a way of classifying acts and determining responsibility for such acts. Thomas Aquinas and clarified and changed the technical vocabulary but adopted much (...) from their views on knowledge and moral responsibility. A similar development took place in the understanding of virtue. Philip and others discussed the nature and unity of the virtues in the context of a patristic inheritance that was largely influence by Stoicism. Thomas Aquinas was among the first to discuss the connection between specifically distinct virtues, bringing to bear Aristotle’s description of prudence in Book VI of the Nicomachean Ethics. Moreover, whereas previous thinkers had primarily distinguished between political and theological virtues, Thomas distinguished more carefully between both infused and acquired moral virtues, and theological virtues that are only infused. He explained that the intellectual virtues, although better in themselves, are inferior to the moral virtues when it comes to making a good human being. Debates over the role of happiness in ethics were related to such distinctions. Early generations had focused primarily on the role that moral and theological virtue plays in its role as leading to happiness in heaven. In contrast, some Aristotelians seem to emphasize the priority of intellectual virtue over moral virtue, and consequently the life of the philosopher over the life of the citizen. Thomas Aquinas distinguished between the different perfections of intellectual and moral virtue, and distinguished carefully between the imperfect happiness of this life and the perfect happiness of the next. Although Thomas brought these issues together in an admirable synthesis, few of his contemporaries thought that he had successfully addressed these issues. (shrink)

Beginning with the well-knowncyber-rape in LambdaMOO, I argue that it ispossible to have real moral wrongs in virtualcommunities. I then generalize the account toshow how it applies to interactions in gamingand discussion communities. My account issupported by a view of moral realism thatacknowledges entities like intentions andcausal properties of actions. Austin's speechact theory is used to show that real people canact in virtual communities in ways that bothestablish practices and moral expectations, andwarrant strong identifications betweenthemselves and their online identities. Rawls'conception (...) of a social practice is used toanalyze the nature of the wrong and thestage-setting aspect of engaging in a practice. (shrink)

I argue that the essence that is actualized by existence is the essence that is a determinate nature in an individual and not the essence absolutely considered. This essence in individuals has a potential being that is actualized by existence. This thesis has important consequences for the essence/existence distinction in Thomas Aquinas.

This article reports the results of a study of attitudes of future business executives towards issues of social responsibility and business ethics. The 455 respondents, who were MBA students during 1985 at one dozen schools from various regions in the United States, were asked to respond to a series of open-ended and closed-ended questions. From the responses to the questions the authors were able to conclude that future executives display considerable sensitivity, though to varying degrees, towards ethical issues in business. (...) Women, in particular, tend to evince strong feelings regarding such issues. (shrink)

Nicolas Malebranche is now recognised as a major figure in the history of philosophy, occupying a crucial place in the Rationalist tradition of Descartes, Spinoza and Leibniz. The Search after Truth is his first, longest and most important work; this volume also presents the Elucidations which accompanied its third edition, the result of comments that Malebranche solicited on the original work and an important repository of his theories of ideas and causation. Together, the two texts constitute the complete expression of (...) his mature thought, and are written in his subtle, argumentative and thoroughly readable style. They are presented in the distinguished translations by Thomas M. Lennon and Paul J. Olscamp, together with a historical introduction, a chronology of Malebranche's life, and useful notes on further reading. (shrink)

The work of Arnon Avron and Ofer Arieli has shown a deep relationship between the theory of bilattices and the Belnap-Dunn logic \. This correspondence has been interpreted as evidence that \ is “the” logic of bilattices, a consideration reinforced by the work of Yaroslav Shramko and Heinrich Wansing in which \ is shown to be similarly entrenched with respect to the theories of trilattices and, more generally, multilattices. In this paper, we export Melvin Fitting’s “cut-down” connectives—propositional connectives that “cut (...) down” available evidence—to the case of multilattices and show that two related first degree systems—Harry Deutsch’s four-valued \ and Richard Angell’s \—emerge just as elegantly and are as intimately connected to the theories of bilattices and trilattices as the Belnap-Dunn logic. (shrink)

Putting Karl Rahner and Michel Foucault in conversation shows the space of overlapping concern in their work for the relationshipbetween subjectivity and knowledge, while introducing new questions about power and history in this relationship. Both fomenta respect for mystery, through Rahnerian “transcendence” and Foucauldian “rescendence,” that while not the same, may yet beunderstood as convergent without a fully realized connection. In other words, the relation between Rahner and Foucault may beposed as “asymptotic.”.

James of Viterbo’s ethical writings focus mostly upon happiness and virtue. His basic approach is Aristotelian. Although he is not a Thomist in the sense that some of his contemporary Dominicans were, he frequently quotes or paraphrases Thomas while arguing for his own positions, especially in response to views defended by such figures as Giles of Rome, Godfrey of Fontaines, and Henry of Ghent. James departs from Thomas by arguing that all acquired virtue is based on an ordered (...) self-love. James’s emphasis on self-love is in turn supported by his own understanding of willing and happiness, which involves a Neoplatonic account of the ratio boni as consisting in unity. Consequently, many aspects of James’s Aristotelian moral thought are ultimately based upon an understanding of the good that has roots in Neoplatonic authors. (shrink)

Can computer systems ever be considered moral agents? This paper considers two factors that are explored in the recent philosophical literature. First, there are the important domains in which computers are allowed to act, made possible by their greater functional capacities. Second, there is the claim that these functional capacities appear to embody relevant human abilities, such as autonomy and responsibility. I argue that neither the first (Domain-Function) factor nor the second (Simulacrum) factor gets at the central issue in the (...) case for computer moral agency: whether they can have the kinds of intentional states that cause their decisions and actions. I give an account that builds on traditional action theory and allows us to conceive of computers as genuine moral agents in virtue of their own causally efficacious intentional states. These states can cause harm or benefit to moral patients, but do not depend on computer consciousness or intelligence. (shrink)

Critics of John Rawls' conception of a reasonable pluralism have raised the question of whether it is justified to demand that religious individuals should 'bracket' their essential, identity-constituting convictions when they enter a political discourse. I will argue that the criterion for religious beliefs of being justified as grounds for political decisions should be their ability of being 'translatable' in secular reasons for the very same decisions. This translation would demand 'epistemic abstinence' from religious believers only on the basis of (...) a rigid distinction between the spheres of private opinions and public reasons. To give a more adequate account of the relation between religious beliefs and political reasons in a pluralistic society it seems to be helpful to make use of Niklas Luhmann's functionalistic theory of religion. Key Words: democracy and religious beliefs • philosophy of religion • pluralism • political liberalism • political theory. (shrink)

Thomas Aquinas (d. 1274) held two theses that might seem incompatible to contemporary readers, namely 1) that an act of faith is reasonable even by the standards of human reason without grace, and 2) that this act surpasses the power of such unaided human reason. In the later Middle Ages, many theologians who were not Thomists held that someone who performs acts of infused faith must also perform such acts through an acquired faith that is based on natural reason. (...) I argue that debates with Protestants and Jesuits caused Dominican Thomists to clarify and develop Thomas Aquinas’s understanding of the traditional position that acts of faith surpass natural human abilities in such a way as to reject the older non-Thomistic understanding of acquired faith. This enquiry will show that major early modern disputes over the authority of Scripture and the source of faith are at least partially rooted in differences among medieval scholastic theologians. Although the Protestants and the Jesuits adhere to distinct confessions, their theological views on faith are based in part on an acceptance of or reaction to Scotistic and nominalist medieval views. Thomists drew on the same resources to respond to non-Thomistic medieval theologians, Protestants, and Jesuits. (shrink)

This dissertation uses the context of the thirteenth-century debate about the natural love of God over self to clarify the difference between the ethical system of Thomas Aquinas and that of John Duns Scotus. Although Thomas and Scotus both believe that such love is possible, they disagree about the reasons for this position. ;Early thirteenth-century thinkers, such as William of Auxerre and Philip the Chancellor, were the first to distinguish between a natural love of God and charity, which (...) is a love assisted by grace. Thomas Aquinas' approach to the issue is original. According to Thomas, since human beings are part of a political whole and also part of a whole whose good is God, it follows that they have a natural inclination to love the common good and God more than themselves. Although Thomas' position and his corresponding interpretation of Aristotle were upheld by Godfrey of Fontaines and Giles of Rome, it was severely criticized by James of Viterbo, who argued that the part always seeks its own good. ;John Duns Scotus makes the same criticism of the part/whole argument, although Scotus emphasizes that the human will is free to act against the natural inclination for self-perfection. Scotus clearly distinguishes between the will and nature. ;The conclusion of the dissertation argues that the debate prefigures the modern shift sway from an ethics based upon natural inclination along with the modern tendency to understand morality as a limitation of self-interest. Moreover, it is argued that modern Thomists need to take into account Thomas' original emphasis on natural inclination and the priority of the common good. (shrink)

Contrary to some recent self-styled “linguistic pragmatists” who seek to dispense with the purportedly obsolete term “experience”. this essay attempts to show that pragmatism cannot cogently dispense with experience, understanding that term in its Deweyan sense as “culture” and not some sort of mentalistic perception or state. Focusing on Robert Brandom’s recent Perspectives on Pragmatism, I show how the very assumptions that Dewey meant to call into question with his “instrumentalist turn” in 1903 are enshrined in Brandom’s “new and improved” (...) form of pragmatism. Judged in terms of its pragmatic consequences, Brandom’s linguistic pragmatism returns to the well trodden paths and problems of analytic philosophy and not the radical approach that Dewey’s “cultural naturalism” (Dewey’s name for his philosophy) offers. The fundamental issue is not, I contend, between types of pragmatism at all but between conceptions of human nature and what a human life is. John Stuart Mill once said of Bentham that, for an empiricist, he had really very little experience, especially of human nature. I am afraid that the same judgment here is passed on those wishing to dispense with experience and somehow retain pragmatism. (shrink)

Thomas M. Izbicki - Becoming God: The Doctrine of Theosis in Nicholas of Cusa - Journal of the History of Philosophy 45:4 Journal of the History of Philosophy 45.4 660-661 Muse Search Journals This Journal Contents Reviewed by Thomas M. Izbicki Rutgers University Nancy J. Hudson. Becoming God: The Doctrine of Theosis in Nicholas of Cusa. Washington, D.C.: The Catholic University of America Press, 2007. Pp. xiii + 218. Cloth, $59.95. Students of the thought of Nicholas of Cusa (...) know that he used the Greek term theosis and identified it with the Latin filiatio, becoming a "son." Nancy Hudson has given us in this volume a thoughtful, well-written study of what Cusanus meant by the term and how this enters into his thought on God and humanity. The book covers the Greek.. (shrink)